Astrocyte-Originated ATP Protects A 1-42-Induced Impairment of Synaptic Plasticity
نویسندگان
چکیده
منابع مشابه
Astrocyte-originated ATP protects Aβ(1-42)-induced impairment of synaptic plasticity.
Activated microglia and reactive astrocytes are commonly found in and around the senile plaque, which is the central pathological hallmark of Alzheimer's disease. Astrocytes respond to neuronal activity through the release of gliotransmitters such as glutamate, D-serine, and ATP. However, it is largely unknown whether and how gliotransmitters affect neuronal functions. In this study, we explore...
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By forming close contacts with synapses, astrocytes secrete neuroactive substances and remove neurotransmitters, thus influencing the processing of information by the nervous system. Here, we review recent work on astrocytes and their roles in regulating neuronal function and synaptic plasticity. Astrocytes are organized as networks and communicate with each other, thereby affecting larger neur...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.6357-11.2012